Dr Charles faces a difficult case involving a patient who wants to remove his own arm, while Halstead and Goodwin try to help a grieving widower.
Dr Halstead decides to resuscitate a patient with stage four cancer, despite the family's objections. The nurses try to improve patient satisfaction.
The Emergency Room's charge nurse is arrested for refusing to run a blood test on a DUI. Dr Halstead seeks legal advice. Dr Manning has a difficult case.
Dr Halstead must face the consequences of the unauthorised resuscitation. A misdiagnosis leaves Dr Manning to make some difficult decisions.