Leonardo da Vinci is arrested on charges of having poisoned Caterina da Cremona. After declaring his innocence, Leonardo recalls his days as an apprentice in the workshop of Andrea del Verrocchio.

As Leonardo's achievements are recognised and his reputation grows, a risky decision could destroy everything he has worked for. The artist sets his sights on the Duchy of Milan and leaves Florence.

Leonardo moves to Milan, determined to obtain the patronage of the Duke Regent, Ludovico Sforza. Reality proves less attractive than expected when Leonardo is asked to devote himself to a great theatrical performance instead of a painting.

When Ludovico asks Leonardo to create an equestrian sculpture in honour of his father, his ambition is stimulated and the artist attempts to exceed the expectations placed on him.

Leonardo receives a commission for a fresco of the Last Supper. After testing his creativity and experimenting with a new technique, Leonardo has to face the consequences of his actions.

Returning to Florence after his years in Milan, Leonardo is offered new opportunities, but does not have the right motivation, until he is asked to paint the portrait of Lisa Gherardini.