Reiji Kirio, owner of Kirio Drugs, enjoys a slow life with Noela the werewolf and Mina the ghost. One day, he encounters Zeral being chased by a knife-wielding woman, Feris, Zeral's overly anxious fiancée. Reiji calms her down. When asked to help Feris, who is acting strangely, what will Reiji brew in his drugstore?

Reiji creates a new medicine, Dishwashing Detergent Scrubba-dub-dub, for Mina, who is delighted by its magical results. He then gives the detergent to Rena at a nearby diner. Doz and Moz from the Red Cat Brigade get involved, but Annabelle, their leader, controls the situation after they chase Reiji.

A gentleman visits Kirio Drugs, now popular due to Reiji Kirio's medicines. The man, a butler for Mrs. Fram, the town lord's wife, invites Reiji to the manor. Mrs. Fram requests a potion to look younger for a dinner party in five days. Though doubtful, Reiji creates Beautiful Belle's Beautiful Skin Gel. However, her daughter Elaine overhears the exchange...

Reiji and Noela visit Rabbit Tavern for lunch, thrilling Noela as it's her favorite restaurant. Suddenly, they hear shouting inside and find the owner and his daughter, Rena, arguing with a rival restaurant owner who has stolen their customers and plans to take over Rabbit Tavern. Seeing Rena's sadness, Reiji decides to help save the restaurant.

The town is bustling with preparations for the Kalta Festival, featuring a hunting competition where the best archers hunt monsters. Kururu, a young elf, has been the champion for years. His younger sister, Ririka, visits Kirio Drugs, seeking Reiji's help. She wants a medicine to improve her archery skills, hoping to beat Kururu and earn his respect, no longer being treated like a child.

Noela, a strong werewolf, accidentally breaks all of Kirio Drug's knives. After being scolded by Reiji, they go to a tool store for new knives. The store is dim and quiet, and Paula, a blue-haired girl with glasses, finally responds wearily after they call out loudly. Overwhelmed by requests from the Red Cat Brigade and townspeople, Paula had fallen asleep. Reiji decides to help her.