A traumatic car accident fills the ER, Cristina has a crisis of conscience about her deceptive teamwork with Burke, and Izzie pushes the boundaries of her probation.
The race for the Chief's position is on, as the doctors compete for Richard's affections, a surgical patient endangers the lives of those around her, and Meredith's Alzheimer's-stricken mother, Ellis, experiences a change in her medical condition.
Addison, Naomi and Sam rush Archer to Seattle Grace to try and save his life; Owen runs into a significant someone from his past; Izzie employs her fellow doctors in a medical game to teach the interns.
Bailey treats a young mother battling breast cancer, Derek learns more about Mark and Addison's relationship, the interns defend a resident's competence at a hospital staff meeting, and Meredith and Addison examine a couple who find themselves in a rather awkward position.
The Seattle Grace staff continue to mourn George's death; Derek receives a proposition from the hospital board.
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