It's National HIV Testing Day and Max has offered free care to all HIV+ patients. Bloom and Reynolds butt heads over their opposing bedside manners. Iggy eagerly awaits the return of a friend. Sharpe discovers that she may need more hands on with her niece.
Max and Sharpe wake up to a new, more personal dynamic. Iggy calls upon an old contact to help with an explosive situation. Bloom begins a tricky dynamic with her new ED residents and Reynolds finds himself in an awkward position with Dr. Baptiste and Dr. Lyn Malvo.
Max works to find a new normal three months after the accident and the birth of his daughter. Kapoor grapples with the stigma of aging. Iggy has a successful day that inspires a life-changing idea. Reynolds deals with an unreliable new intern.
Sharpe has an important realisation that will affect her career. Meanwhile, Max and Reynolds take on uncharted waters when a young patient comes to New Amsterdam with symptoms of a heart attack.
With the hospital on lockdown after the Rikers patients' escape, Sharpe and Max find themselves in a situation that could cost them their lives. Meanwhile, Bloom must put aside her pain to help a patient in need, while Iggy is forced to face the issues in his marriage.
