Doctors Manning and Rhodes suspect that two separate cases involving sick babies may be connected. A homeless patient's upbeat disposition enlightens Doctors Halstead and Charles, and Dr Choi and a Navy corpsman deal with the toll of gang violence.
Sharpe struggles when a case hits too close to home and Iggy uncovers a patient's surprising past. Meanwhile, Floyd makes progress in his personal life after some difficult news.
A renowned paediatric cardiac surgeon proves unfit for surgery, a Dolly Parton drag queen collapses on stage, Nic and Conrad suspect a patient may be the victim of sex trafficking, and Nadine delivers some surprising news to Devon.
The provocative medical drama follows a group of doctors at Chastain Memorial Hospital, as they face personal and professional challenges on a daily basis while fighting for their patients.
Michael must deal with a terrorist who recruits him to steal hardware from the Department of Defense. Sam and Jesse discover Michael's life might be in danger.