Two sets of twins born in the small town of Jupiter Hollow are mixed up by a confused nurse. The parents -- one set poor local farmers, the other wealthy socialites just passing through -- are none the wiser and take the twins home. Now, some 40 years later, the wealthy pair (Bette Midler, Lily Tomlin) are involved in a business deal to buy and close down a factory in Jupiter Hollow. Hearing the news, the other set of twins travels to New York City to try and stop the sale.