As the threat of Hive looms even more strongly, existing loyalties are put to the test and the team of S.H.I.E.L.D. agents are forced to come up with a decisive resolution.
The team reels from its losses as Hive continues to draw Inhumans to his side. Agents Fitz and Simmons get a lead that could stop the maniacal Inhuman forever.
Coulson and the team search for the Inhuman who is killing other Inhumans; May worries Hunter's mission to bring down Ward is becoming too personal.
As tensions rise between S.H.I.E.L.D. and the Inhumans, Skye finds her torn between the groups. Meanwhile, Coulson reveals a secret.
S.H.I.E.L.D. puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.