Alex and Jo go on a road trip to Iowa to find Alex's mum. Meredith gives a presentation on her mini-livers project, which attracts a lot of attention.
During presentations at the Innovation Prototypes Day, Arizona shares some cookies that, unbeknown to her, contain a special ingredient.
An agent from US Immigration and Customs Enforcement searches the hospital for an employee, Alex's patient wants to leave the hospital to enjoy her final days, but Alex feels differently, and Arizona treats Matthew Taylor's baby.
Things do not go as planned at Alex and Jo's wedding. The stress from the past year has taken a toll on Bailey, making her re-evaluate some of her decisions.
New doctors continue to shake up the hospital, Meredith bonds with a patient and Jackson struggles with the meaning behind recent experiences. Meanwhile, Jo forms an unexpected alliance.