Scientist Shane Brown (Vincent Gallo) neglects his new bride (Tricia Vessey), instead spending their honeymoon searching for an old colleague who disappeared after a research paper he had written was discredited by the medical community. It turns out that Dr. Semeneau is living in obscurity in order to protect his wife (Béatrice Dalle), whom he keeps prisoner in a room with boards nailed across the doorway. The narrative unfolds the dark secret that drives each party.