S.H.I.E.L.D. puts it all on a line to survive a fight that blurs the line between friend and enemy; the team must make sacrifices that will alter relationships forever.
As tensions rise between S.H.I.E.L.D. and the Inhumans, Skye finds her torn between the groups; Coulson reveals a secret.
Coulson and the team search for the Inhuman who is killing other Inhumans; May worries Hunter's mission to bring down Ward is becoming too personal.
The team reels from its losses as Hive continues to draw Inhumans to his side; agents Fitz and Simmons get a lead that could stop the maniacal Inhuman forever.