All reassess their personal lives after witnessing a chance reunion between two long-lost lovers in the emergency room; Karev treats a troubled teen (Demi Lovato); Meredith shares her suspicions with Cristina.
A woman without a uterus asks Jake and Addison to help her have a baby; Amelia treats a woman with Parkinson's disease who is habitually unfaithful; Violet struggles with her life as a stay-at-home mom.
The team closes in on a serial killer (Tim Curry) holding Detective Spicer's daughter hostage.
During a series of rolling blackouts, the team tracks a serial killer in Los Angeles who targets families.