Peter Romancek, a young man and his mother move to the town of Hemlock Grove that gets in alert after a young girl's body is found and the strange rumours about Peter's nature lead the townsfolk to suspect him.

Roman Godfrey confronts Peter who was investigating the scene of the crime by himself and the two become friends, with Peter sharing his secret with him. Meanwhile, Roman's cousin Letha discovers that she is pregnant, but claims that the child's father is an angel.

A second body is found by Christina, a local student and Dr. Clementine Chasseur arrives at the town to investigate the murders. Meanwhile, Roman decides to find the killer by his own and asks for Peter's help.

Letha starts feeling attracted to Peter, who looks for the help of his cousin Destiny to use her powers in order to track down the murderer. However, to do that, Roman and Peter must bring her some remains of one of the victims and they get in trouble when the police arrives at the cemetery with the same idea.

The shovel left at the grave is traced back to the Godfrey estate. Destiny helps Roman and Peter to make sense of things. We get some back story to Dr. Chasseur. A party is thrown at the tower to celebrate the Godrey Institute.

Peter and Roman's investigation takes them to the Godfrey's old steel mill where they find a missing piece of the puzzle. Meanwhile, Christina has a date with a friend that turns wrong when the memories of the body she found come back to torment her.