Jason and the team find innocent civilians in need of rescue just as enemy forces close in on them; the team debates whether to tell Ray that his wife has gone into labor.
Michael seeks revenge against Whistler and Gretchen and uncovers unbelievable news; Lincoln and Michael are reunited with the gang and get an offer from a Homeland Security agent; Mahone experiences a devastating loss; T-Bag is deserted.
Michael and the team have a day to find the next cardholder or they risk going back to prison; Mahone seeks revenge on Wyatt, who is attempting to get information on Sara's whereabouts; T-Bag finds a new identity and gets a job offer.
Michael, Lincoln and Sucre have to crash a police benefit to get the next card key; Sarah falls back into an old habit; on his first day of his new job, T-Bag runs into some old friends and arouses suspicion.
Mahone finds resolution; Gretchen and a Company man get cozy; Michael's medical condition gets worse; a member of the team makes the ultimate sacrifice in the search for Scylla.