Callie and Derek collaborate on a brain mapping project; Meredith thinks about continuing her mom's research; Shane's guilt persists.
While investigating a homicide with Catherine (Marg Helgenberger), a shocked Gil (William Petersen) discovers that a prime suspect has been missing for decades; Warrick and Sara (Gary Dourdan, Jorja Fox) try to explain what seems like a physical impossibility.
The team hunts for a pedophile suspected of kidnapping an FBI agent's children and murdering his wife.
Buffy learns more about her sister Dawn when a menacing force finds its way to Sunnydale; Buffy's mother falls ill for no apparent reason.
When Nick inherits some money from his late father, Jess is determined to put the funds to good use and secretly tackle Nick’s box of unwanted responsibilities – aka bills. Meanwhile, Schmidt tries to find meaning in life and asks for guidance from Rabbi Feiglin (guest star Jon Lovitz).
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