A patient at the hospital is brain dead after falling into a construction site; her two sisters must decide whether or not to keep her alive.

Castle reconnects with Kyra, a former girlfriend, on her wedding day and sparks fly. Beckett picks up on the obvious connection between the two of them, making her a little jealous.

Peter's toy company is bought out by the Eldorado Cigarette Company and the toys are used to market cigarettes to children. When Peter confronts his new bosses, he is unexpectedly made the CEO and dispatched to congress.

When Earl and Billie are rendered unconscious after a double accident, Earl's fevered mind creates a sitcom world where he is married to Billie.

Bitter towards karma after his release from prison, Earl reverts to his old criminal ways. However, karma catches up to him in the shape of a car and Billie.

Billie believes Earl is spending more time with his list than with her, and retaliates by undoing each of his good deeds in a bid to get his attention.

Earl is concerned over the things he and Billie don't have in common, until he learns about her Karma list, and helps her make things up to a supermarket grocery bagger.

As Earl recovers from his coma, he believes that karma wants him to reconnect with Billie. Meanwhile, Darnell and Joy move into the Crab Shack.

Earl has no one to visit him on conjugal-visit day at the prison; Frank's girlfriend breaks up with him; Joy gets herself into a messy situation with Catalina.

Randy takes it upon himself to care for his comatose brother. Randy, Joy and Darnell also work together on Earl's list.

Earl turns his attention to his Karma list after listening to his friends' romantic advice. Along the way, he realises that atoning for his past mistakes is bringing about a change in Billie.

While Earl is in a coma, Randy discovers that every time he checks an item off the list, Earl gets a little better. He asks Joy and Darnell to help solve the mystery of a stolen motorcycle.

As the doctors count down the minutes to pull the plug, Earl's friends scramble to seek help from miracle healer Gerald.