As tensions rise between S.H.I.E.L.D. and the Inhumans, Skye finds her torn between the groups. Meanwhile, Coulson reveals a secret.
S.H.I.E.L.D. puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.
Coulson and the team search for the Inhuman who is killing other Inhumans; May worries Hunter's mission to bring down Ward is becoming too personal.
The team reels from its losses as Hive continues to draw Inhumans to his side. Agents Fitz and Simmons get a lead that could stop the maniacal Inhuman forever.