The doctors of Grey Sloan Memorial must contend with the COVID-19 pandemic; an unintentionally started fire has first responders from Station 19 bringing patients into the hospital for treatment.
With the absence of Captain Pruitt, Andy and Jack try to navigate how to work together; a car accident puts the crew's lives at risk.
After some tense and traumatic experiences, the firefighters get a visit from a psychologist.
Andy and Sullivan find a way to stay connected; Ben confronts a tough loss; Jack and Inara grow closer; while off-duty, the crew jump into action to help a mother in distress, but their heroic efforts spark conflict with police officers.
When the COVID-19 pandemic hits Seattle, the Station 19 crew lean on each other for support; Andy tries to make sense of her mother's return; a group of teenagers unintentionally start a wildfire.