Chuck learns that Casey's ex-girlfriend is about to marry a Russian arms dealer and urges him to fight for her; Capt. Awesome and Ellie reach a tough point in their relationship.
A bus accident robs House of several hours; as his memory slowly returns, he realises that one of his fellow passengers was exhibiting signs of a deadly illness, so he races to unlock the secrets in his brain.
Daniel reverts to his old hard-partying ways; a tell-all writer (Leslie Jordan) with Fey Sommers' diaries starts stalking the Meades.
Betty tries to avoid Daniel, Christina and Henry; Alexis gets asked out on her first date as a woman; Amanda begins a flirtation with a designer (Mykel Shannon Jenkins) whom she assumes is gay.
Felicity looks for the right opportunity to invite Ben to her first college party; Noel hopes to get a dance in before chaos reigns.