Bailey treats a young mother battling breast cancer; Derek learns more about Mark and Addison's relationship; the interns defend a resident's competence at a staff meeting.
The agents are called in to investigate the murder of a convict who served nine years for rape and murder, but was released when new DNA evidence exonerated him.
The team investigates when a wealthy couple is murdered in their own home after a Super Bowl party, and learn that someone placed an emergency call to quote Bible passages in the seconds before the murders.
When NASA tells a nervous Wolowitz that his space mission has been rescheduled, he tries to use the wedding as an excuse not to go, but he's forced to agree when he realises that Bernadette's father only likes him because he's an astronaut.
Paul stands in the way of Susan receiving a kidney transplant; Tom passes up a lucrative job to continue working with Carlos; Andrew's alcohol consumption increases, worrying Bree.