Stefan and Elena are stranded in a remote location, where Stefan gets philosophical about Damon and Elena's relationship; Luke and Liv form a dangerous new strategy; Bonnie finally admits the truth.
Just when Derek's condition seems to be improving, a severe complication arises; when Cain's former girlfriend is admitted to the hospital for surgery, the doctors finally get a glimpse into his personal life.
Abbie and Ichabod look for clues to stop the evil in town; Abbie receives an unexpected visit from Andy Brooks.
The Inner Circle makes a plan to raid a mutant detention facility and the team has to stop them; The Struckers try to rebuild their broken trust.
Reeva Payge is left completely in charge of the Inner Circle when she purges everyone who disagrees with her.