When Sheldon is forced to take a vacation by the university, he goes to work with Amy in her neurobiology lab. Meanwhile, Bernadette wants Howard to sign a pre-nuptial agreement.
On the night after the election, Selina discovers a possible road to victory; Amy must make a decision; Catherine begins a documentary project; Mike announces that he and Wendy are adopting a baby; Dan considers a new career.
The stress of McGee and Delilah's upcoming wedding lands Delilah in the hospital; the NCIS team investigates the mysterious death of a healthy, young petty officer aboard a Navy destroyer.