Hannah is confronted by her classmates after leaving a non-apology apology letter in their cubbies. After getting rejected at yet another interview, a frustrated Shoshanna spends a day with Ray. Creative and romantic tensions with Marnie and Desi reach breaking point.

Hannah finds herself doing very little with her free time, while a visiting Elijah has become the social butterfly of Iowa. Ray gives Marnie a wake-up call about Desi's intentions before their meeting with a record label. Shoshanna aces, then blows, a job interview.

Hannah settles into her new life and discovers she can get more for her money, rent-wise, in Iowa. At her first seminar, Hannah warns her fellow workshop writers that her piece might trigger some intense emotions - but doesn't get the feedback she had hoped for.

Dr Manning and Dr Charles treat a teenage girl whose rapidly changing set of symptoms has everyone perplexed.

Dr Rhodes persuades Dr Latham to accompany him on a medical trip out of town. Meanwhile, an 8-year-old cancer patient wants to give up his battle.

Dr Charles' daughter joins the epidemiology department and is immediately put to task when cases of a rare infection are discovered.

Halstead and Manning deal with arguing brothers, one of whom needs a replacement kidney. One of Dr Reese's patients comes to a crossroad.

A traumatic multi-car accident during a blizzard stretches the hospital staff to the limit; Rhodes and Latham make difficult decisions in triage; Choi handles a severely burnt patient who has a final request.

On a busy night, Dr Reese deals with having to pronounce several patients dead. April is pressured to slow down, and Dr Charles has important news for Dr Latham.

Hank puts the attendants of a bar mitzvah party in quarantine when symptoms of a disease appear, and considers announcing a possible outbreak. Meanwhile, Evan learns more about Divya's personal life.

Dr Rhodes begins his cardiothoracic surgery fellowship, but gets off on the wrong foot with his new boss, Dr Latham. Meanwhile, Dr Choi begins his life as chief resident, and Sarah is caught off-guard by Dr Charles.

Family secrets bubble up to the surface when Maggie's sibling arrives back in town. Dr Manning works on a case that is getting lost in translation.

A young cancer patient struggles to tell her parents about her condition. Dr Reese turns to Dr Charles and Detective Lindsay for help with a troubled young man. Meanwhile, a teen science geek and her friends impress Dr Choi and Natalie.

Dr Manning struggles to treat a comatose woman who is unexpectedly pregnant. Dr Reese is contacted by a troubled teen in a psychiatric facility.

A heart transplant patient gets into a car accident, revealing issues that could complicate her surgery. The police officer who arrested Maggie is brought to Chicago Med with a serious injury.

The shooting of Dr Charles moves to the courtroom. Dr Halsted and Dr Manning work on a heart-wrenching case.

Dr Manning goes to extreme measures to help a fearful pregnant woman and Dr Choi and April try to strike a balance at work. Also, Dr Charles and Dr Reese continue to disagree about their patients.

When Goodwin receives financial complaints from the hospital board, she is forced to implement new guidelines that cause headaches for the doctors.

Robin is admitted back into the hospital with more complications. Rhodes faces competition from a new hotshot doctor.

Dr Manning is injured while helping the victim of a drive-by shooting, while Dr Rhodes learns surprising information about an ex-girlfriend.