Kara gains a valuable new ally when The Flash is catapulted into her universe. Can she convince him to take on Silver Banshee and Live Wire?
A standoff ensues between the DEO and Astra's forces, Kara tries to refute Cat's allegations that she is Supergirl and Non, Astra's husband, kidnaps Hank.
A parasitic alien traps Kara in a dream where her home planet is intact and her family is alive; Alex, Hank and the DEO have to fend off a Kryptonian attack without Kara.
The truth behind Fitz's turn is revealed, and it could bring down all of SHIELD. Turning on HYDRA, May sneaks a Terrigen crystal to Johnson, so she can gain her inhuman abilities within the Framework.