Bailey finds herself in the middle of an argument with patients' families as they await news about their children who were injured in a fire; Winston surprises Maggie; Amelia and Link try to have some fun as new parents.
A group of doctors at a Seattle hospital, including several who began their careers at the facility as interns, try to balance life and work as they are pushed to their limits every day on the ward and off.
Sookie hatches a dangerous plan to take down the H-Vamps, even as Vince and his vigilantes pose an equally serious threat. Lafayette gets high with James; Jason eyes a future with Violet. Pam offers Eric a reason to return to Louisiana - and be the vampire he once was.
An elusive girl may hold the key to a mystery that brings the team to Asia. Meanwhile, a secret jeopardises Skye's relationship with the team.