Born in Ontario to a Jewish family, Peaches began her musical career in the 1990s as part of a folk trio, Mermaid Cafe. In 1995, she established a rock band, The Shit. That year she also released her first solo album, Fancypants Hoodlum. Moving to Berlin, Germany, it was here that she was signed to the Kitty-Yo label and released her second album, The Teaches of Peaches (2000). Touring as the opening act for bands like Marilyn Manson and Queens of the Stone Age, she subsequently released her third album, Fatherfucker (2003).
Her songs have been featured in movies such as Mean Girls, Waiting. ., Jackass Number Two, My Little Eye, Drive Angry, and Lost in Translation. Her music has also been featured on television shows such as Lost Girl, The L Word, Ugly Betty, South Park, 30 Rock, True Blood, Full Frontal with Samantha Bee and has been used for the promotion of Dirt. Peaches performed guest vocals on Pink's album Try This, on the song "Oh My God", on the Chicks on Speed album 99 Cents, on the song "We Don't Play Guitars", on Christina Aguilera's 2010 album Bionic, on the song "My Girls" (which was produced and co-written with Le Tigre) and recently on Major Lazer's 2013 album Free the Universe on the song "Scare Me" featuring Timberlee.