All reassess their personal lives after witnessing a chance reunion between two long-lost lovers in the emergency room; Karev treats a troubled teen; Meredith shares her suspicions with Cristina.
Dr Sturgis recommends Missy and Sheldon for a study on twins, but Mary isn't pleased when the results go to Sheldon's head.
Disaster looms as Lois joins a book club, leaving Hal in charge of the boys, and a hitchhiking Francis has to do whatever the trucker dares him, or he's walking.
The team hunts for the killer of a struggling gold prospector. Hightower gets a closer insight into Jane's methods when she temporarily replaces an injured Lisbon as his partner.
Malcolm reveals Cynthia's big secret to Reese, Dewey helps Hal overcome his fear of kites, and a neighbour makes amends to Lois and Francis becomes enchanted with a totem pole.