Michael seeks revenge against Whistler and Gretchen and uncovers unbelievable news. Lincoln and Michael are reunited with the gang and get an offer from a Homeland Security agent; Mahone experiences a devastating loss and T-Bag is deserted.
Michael and the team have a day to find the next cardholder or they risk going back to prison; Mahone seeks revenge on Wyatt, who is attempting to get information on Sara's whereabouts; T-Bag finds a new identity and gets a job offer.
While Linc, Sucre, Sara, and Roland follow a Scylla cardholder to Vegas, the others go after T-Bag. Meanwhile, Don confronts Pad Man.
One of the gang makes the ultimate sacrifice in a bid to reach Scylla, while, with Wyatt captured, Mahone reaps revenge for his son's murder.
Michael and co continue to hunt for the Company's cards containing the top secret information, but he, Lincoln and Sucre must crash a police benefit if they are to obtain the next card on the list.