Meredith volunteers to run the ER for a night in hope of proving that she is chief-resident material; Bailey and Eli (Daniel Sunjata) get into mischief; Adele comes to the hospital as a patient.
When one Kansas family goes missing and another one turns up dead, the team looks for a link between the cases; Beth has surprising news for Hotch.
The BAU investigates a case in Rossi's hometown that involves both his personal and professional lives.
The team profiles a killer targeting an emergency room doctor; Hotch goes missing.
The team pursues a serial killer in Milwaukee, with three fewer members since Hotch asked to be transferred, Prentiss quit, and Gideon is missing.