House follows the professional and personal trials of the gifted but bitter doctor Gregory House (Hugh Laurie) as he literally does whatever it takes to diagnose and treat the sick. As he obsessively rants, terrorizes patients, and browbeats his medical team, including Robert Chase (Jesse Spenser), Allison Cameron (Jennifer Morrison), Eric Foreman (Omar Epps), and Remy Hadley (Olivia Wilde), he fights with supervisors like Lisa Cuddy (Lisa Edelstein) in order to bend the rules to help his patients. Luckily, oncology department head and friend James Wilson (Robert Sean Leonard), helps him navigate through the ethical dilemmas.