Bailey and a team of surgeons must remove a young girl's inoperable tumor; as the new head of trauma, Owen Hunt challenges the surgical abilities of the residents and the attending doctor's methods.
When Francis is left in charge of his brothers, mayhem ensues, and Malcolm gets hurt, requiring hospitalization.
Grace reveals her ex-boyfriend's faults to his bride at the wedding rehearsal; Elliot's mother (Rosie O'Donnell) demands that Jack never see him again.