After Banfield defends herself from a street criminal, she and Dr. Gates treat a young gymnast with suspicious injuries indicating abuse. Dubenko's back on the surgery team.
When a teenage wrestler comes into the ER with severe vomiting, Pratt discovers that the cause of the problem is very serious; Gates tries to help a child with a deadly disease; two volunteer police officers come in with gunshot wounds.
Gates and Neela try to revive Meg after they find her unconscious in her car; Sam thinks she knows who set fire to her home; tensions mount as Ames (Forest Whitaker) gets more desperate for revenge.
The new chief prepares to make changes in the ER; Kovac postpones his honeymoon to travel to Croatia to be with his ailing father; Sarah fears she might be taken away.
Kovac and Abby acclimate to their new roles as husband and wife; Hope and Morris enjoy the honeymoon suite; Pratt hopes to win over a new woman; a new doctor (Stanley Tucci) in the ER means business.