Ichabod, Abbie, Captain Irving and Jenny Mills join forces and face the Headless Horseman. While staring down this nemesis, Ichabod is shocked by game-changing information about the Horseman’s true motive.
Conrad's plans for a heart transplant patient are derailed; Conrad risks his job to rectify the situation; after a file goes missing, Nic grows suspicious of one of the doctors; Devon must make a split-second decision for a patient.
Ichabod Crane and Lt. Abbie Mills concoct a daring plan to try to rescue Ichabod's wife, Katrina, from the Headless Horseman by resurrecting a Frankenstein-like monster created by Benjamin Franklin. Meanwhile, Frank Irving faces new trouble after revealing the true details of his encounter with a demon, and Jenny Mills finds herself at odds with the new sheriff in town.
When Capt. Iriving’s daughter, Macy, becomes the target of evil forces, he makes a desperate plea to Crane and Mills for help, and seeks answers that lie within Washington's Bible. Meanwhile, a frightening chapter of Jenny's past is revealed.
Conrad battles a group of overly aggressive attending physicians; Mina goes out of her way to help a young man from her neighborhood who almost mugged her; Nic enlists Devon's help.