Jeff (Jason Segel) lives in his mother's basement. A fan of the movie Signs, he believes that the world operates in signs and connections, if you're just open to them. One morning, he receives a call: a wrong number asking for "Kevin." Going out to buy wood glue for his mom (Susan Sarandon), he spots a kid with "Kevin" written on his jersey and -- believing this is the key to something -- starts following him. Soon Jeff runs into his slightly more successful brother, Pat (Ed Helms). Pat has a job and is married, but he believes that his wife (Judy Greer) is having an affair. Jeff wants to help his brother, but more signs are calling him. Can Jeff find the connection between all these events?