In February, 2020, a luxury cruise ship carrying 3,700 people arrives in Yokohama Port. One passenger, who disembarked in Hong Kong, was confirmed to have the new coronavirus. The coronavirus has since spread rapidly on the cruise ship. More than 100 passengers complain of symptoms. The DMAT (Disaster Medical Assistance Team) is called to the port to respond. DMAT is specialized in responding to natural disasters like earthquakes and floods. They do not have experience or training in dealing with new virus outbreaks. Hideharu Yuki (Shun Oguri), who is a leader in DMAT, and government official Nobutaka Tatematsu (Tori Matsuzaka) command the cruise ship situation at the headquarters. Doctor Yukiyoshi Sendo (Yosuke Kubozuka) and members of DMAT, including Haruto Sanada (Sosuke Ikematsu), decided to board the ship to deal with the situation.