A horrific car accident puts a family's fate in the hands of the Gaffney staff. Ripley questions Lenox and her increasingly reckless behavior.

A family of victims from a house fire are rushed to Gaffney.

Jane defends her - rather Deb's - mom in a divorce suit when Grayson turns down her mom's request since he is already representing Deb's dad. Deb gets a chance to spend time with her mom Bobbi and starts to learn to let go of her old life. Kim represents a dog owner who sues a pet cloning company for breach of contract as he feels this clone is NOT the same dog as his first dog, who was a Westminster champion.

As Jane agrees to be the lawyer for an infamously difficult fashion designer, Kim and Grayson argue on behalf of a client whose sex change has jeopardized her chances at being considered her late spouse's legal heir.

As Jane (Brooke Elliott) represents a lesbian couple that is being denied a chance to attend their senior prom together, Teri (Margaret Cho) enlists Grayson (Jackson Hurst) to help a bailiff who’s been caught in a mail order marriage scam. Meanwhile, Jane is stunned to learn that her boyfriend, Bill, is seeing other women.

On Brennan and Booth’s first official day back at their respective positions at the Jeffersonian and the FBI, things get exciting when remains are found at a fish farm under suspicious conditions, prompting them to investigate. After it’s discovered that someone harvested several of the victim’s internal organs before he was dumped in the water, Angela tracks down the seller and buyer of the organs to try to uncover important details in the case. Meanwhile, Booth readjusts to his position back at the FBI and discovers Aubrey has taken over his old office; Hodgins pushes Angela to showcase her photography work; and Cam struggles with her decision to choose work over her relationship with Arastoo.

Jane attempts to reconcile with Owen while they work together representing a professor who’s been arrested for smuggling drugs. Kim goes up against Grayson’s ex-fiancé Vanessa in a case where Kim represents a woman fighting for rights to a very successful video game she created with her recently deceased boyfriend. Stacy invites a handful of her exes to a “donor party” where she tries to assess who might be the best sperm donor.

As Jane (Brooke Elliott) seeks to ban a dietary supplement that killed a teenage football player, Kim (Kate Levering) fights to save the job of a bailiff who stopped her from being mugged while dressed as a superhero.

Grissom and Warrick investigate the case of young man found dead in the desert, while Catherine and Nick look into the murder of a school dean.

Grissom and Stokes are called on to identify the skeletal remains of a murdered woman, while Warrick and Sara investigate a shooting by a cop.

While Grissom and Sara are called to investigate the death of a woman discovered on a remote trail, Catherine and Warrick try to solve the theft of a costly painting belonging to a multi-millionaire. John Getz guest stars.

An army of surgeons prepares to separate conjoined twins. Asher reconnects with someone from her past. Archer treats a tyrannical boss with a heart problem.

Charles and Archer treat a heart transplant patient who believes his new heart doesn't want to be in his body. Lenox takes a personal day. Hannah discovers a mass on a pregnant woman's ovary.

Grissom and Willows hunt down the Highway I-15 serial killer while the unlikely team of Sidel and Brown are assigned to work on a robbery/murder case together.

Ripley struggles to rescue a woman and her daughter trapped in an abandoned well. Frost is caught off guard by the arrival of an old friend from his TV days. Hannah's big sister gives her some much needed good news.

Goodwin's troubles persist. Charles clashes with his former resident over a depressed patient. Lenox and Ripley treat a car accident victim who recently reunited with his college sweetheart.

A man convicted of arson and the murder of his wife and child seeks assistance from Grissom to help prove his innocence. Meanwhile, Catherine and Nick investigate the underground world of sports gambling when a teenager is murdered at close range.

Grissom investigates a possible suicide at a high-profile construction site.

When the class clown at the local high school is found murdered, the CSI team is called to investigate.

Grissom and his team investigate a murder suspect who is caught red-handed, burying the victims, while Catherine and Warrick take on the case of a woman found dead in a hotel spa.