While on a wheelchair, Sophia manipulates a nurse; Blanche is a stage grandmother.

Lucas and Peyton try to redefine their friendship after Lucas chooses to be with her best friend, Brooke, who is unaware that Lucas and Peyton briefly dated.

While holding a vigil at Lucas' bedside as he lays in a coma, Karen meets Brooke, who is now dating Lucas, and learns from Deb that Deb and Dan are getting divorced.

Nathan must choose which parent to live with after Dan and Deb's divorce.

Peyton introduces hip-hop sensation Lupe Fiasco at the nightclub Tric, while rumors that Brooke is pregnant run rampant. Still dealing with the car accident, Nathan buys a motorcycle, despite Haley's reservations.

A brilliant but terminally ill scientist seeks eternal life by transferring his mind into Data's body.

Brooke deals with giving up her baby, while Lucas deals with the residue of his actions following his game-night scuffle. Haley has a musical breakthrough and Peyton gets news about a ghost from her past. Meanwhile, Nathan and Jamie (recurring guest star JACKSON BRUNDAGE) face their fears together.

Lucas and Peyton finally discuss Lucas' aborted wedding.

Lindsey (Michaela McManus) returns for Jamie's (Jackson Brundage) fifth birthday, giving Lucas hope for their relationship. Dan (Paul Johannsson) divulges a grave secret.

Lucas is crushed by devastating news. Brooke's baby undergoes emergency surgery. Haley wrestles with her decision to record a new album. Skills and Nathan, in an effort to salvage the Ravens' season, employ a risky game plan, and Lucas stuns Peyton with a shocking truth.

As Adam (Sean Giambrone) reluctantly agrees to take dance lessons from Beverly (Wendi McLendon-Covey), Murray (Jeff Garlin) is pressured into talking to the boys about sex.

When Beverly (Wendi McLendon-Covey) complains that Pops (George Segal) is spending too much time with her at home, Murray (Jeff Garlin) takes him back to work at the furniture store. Adam (Sean Giambrone) reluctantly gives away his toys, hoping it will help him get his first kiss.

A friend (Jon Lovitz) fakes illness to get Jerry's sympathy; Kramer obstructs justice.

The search for Nathan becomes increasingly dangerous, and Dan's life hangs in the balance. Brooke is surprised when her father(recurring guest star RICHARD BURGI) returns. And Clay and Quinn reconnect with Logan (recurring guest star PIERCE GAGNON).

Haley receives news of a possible tragedy. Dan's search for Nathan leads him back to his dark past. Clay has a breakthrough in his treatment. Brooke and Julian deal with Xavier (recurring guest star DEVIN McGEE). Chase's concern for Chuck (recurring guest star MICHAEL MAY) pushes him to his limits. Former series stars BARBARA ALYN WOODS and ANTWON TANNER guest star. Haley receives news of a possible tragedy. Dan's search for Nathan leads him back to his dark past. Clay has a breakthrough in his treatment. Brooke and Julian deal with Xavier (recurring guest star DEVIN McGEE). Chase's concern for Chuck (recurring guest star MICHAEL MAY) pushes him to his limits. Former series stars BARBARA ALYN WOODS and ANTWON TANNER guest star.

A gypsy fortune teller predicts disaster for Marcy and good fortune for Al, Steve and Peggy.

Ally’s fantasies interfere with her lawyering, prompting fears that she may be losing her mind; a man who believes his wife never loved him sues for fraud; Fish experiences impotency as he and Ling are about to make love.

When the producer of a hit twenty-something series is murdered, Jessica (Angela Lansbury) does some directing of her own. With Nicolas Surovy, Frederick Coffin.

Monica helps a man who is unable to acknowledge that his son is dying and his unborn grandson is being carried by a surrogate mother.

A missing hunter casts unwanted attention on Brett and the pack, creating tension with Coach Ross. Meanwhile Nick and Dylan try to put their differences aside during The Gates Father/Daughter Dance, with mixed results; and Andie and Charlie's relationship looks like it's headed for smooth sailing, until an unexpected secret turns everything upside down.