S1, E23: With Isaac's (Santiago Cabrera) horrible predictions all unfolding before them, the everyday people with extraordinary abilities face moments of pain and peril in Kirby Plaza with unflinching heroism, as "Heroes" first volume comes to a close -- and the next surprisingly begins. Jack Coleman, Tawny Cypress, Noah Gray-Cabey, Greg Grunberg, Ali Larter, Masi Oka, Hayden Panettiere, Adrian Pasdar, Sendhil Ramamurthy, Leonard Roberts and Milo Ventimiglia also star. Clea Duvall, Lisa Lackey, James Kyson Lee, Missy Peregrym, Zachary Quinto, Richard Roundtree, George Takei and Adair Tishler guest star.