S6, E11: When Grace's (Debra Messing) rebellious, free-loading older sister Janet (Academy Award-winning guest star Geena Davis, "The Accidental Tourist") comes to town to launch her new jewelry enterprise/ folding table subway stand, Grace decides to put her foot down casting her sibling away. However, when her tough love prompts Janet to go corporate by taking a 9-5 job and studio apartment, Grace can't seem to handle her new image. Meanwhile, Karen (Megan Mullally) continues to spurn Lyle's (guest star John Cleese) proposals of marriage, only to have a change of heart after Lorraine (guest star Minnie Driver) stops by for an impromptu visit, to declare her disapproval over Karen's "relationship" with her father. Eric McCormack and Sean Hayes also star.