On an isolated island, a group of teenage delinquents living in a youth center wake up to find themselves alone with no one to watch over them. After much partying, their supervisor appears out of nowhere, feverish and shaking. He suddenly attacks the students. They fight back and kill him accidentally, leaving them no other choice than to flee the crime scene. As they run away, they realize the island has been deserted. Or practically. The few adults they encounter on their journey all seem to be infected by a mysterious epidemic, making them violent and dangerous.