Deadshot returns to Starling City after taking down a U.S. Ambassador and six others overseas. By keeping tabs on A.R.G.U.S.'s manhunt for the assassin Oliver Diggle and Felicity learn that a sting operation is underway to capture Deadshot alive. Diggle is determined to see his brother's killer dead with or without Ollie's help. Meanwhile Laurel takes drastic steps to protect a young witness exacerbating friction between Tommy and Oliver. Later Roy Harper unconventionally pursues all leads to find his new hero but runs afoul of Detective Lance. Back on the island Oliver recalls how Shado helped him incrementally gain confidence with a bow and hit the target for the first time.
Ten years after the animals were cured but at the cost of sterilizing the human population, a new threat rises in the form of "the hybrids," an army of unstoppable lab-made creatures focused on destroying mankind.
Claire and Sean track down a man who had his own deadly encounter with Drill, over 30 years ago.
Claire, Sean, Wes and Lena attempt to unravel the past of a man who first encountered Drill over 30 years ago, which could lead to a way to kill it, before Drill finds a way to murder the man first.