A group of teenagers are driving on the freeway when a skull smashes through their windshield. At the Jeffersonian lab, Brennan tests out a young forensic anthropologist to replace Zack, who has left for Iraq, and she and Cam examine the skull in question. They find it has marks made by human teeth, suggesting cannibalism. The team identifies the victim, a known violin protégé who disappeared after a concert. On a quest to find out what happened to him, Brennan and Booth go into the field. A trail of suspects leads them to a strange cannibalistic society, and the team must string together a gruesome and cryptic series of crimes - provided that Brennan and Booth can survive the newfound tension between them. Meanwhile, Cam suggests that Angela hire a private investigator to track down her ex-husband so she can annul her previous marriage and marry Hodgins, a task easier said than done.
Evelyn reads in the obituaries that her second husband, Harry, has died.
When several people in Los Angeles suffer from seizures as a result of product tampering of over-the-counter medications, Don and his team discover that a former chemist from a large pharmaceutical company is to blame. While tracing the culprit to the Sibley mountains, the team meets up with Special Agent Edgerton (guest star Lou Diamond Phillips), who is tracking a cattle rancher-turned-federal fugitive for selling tainted beef and killing a U.S. Marshall. Megan figures out that their meeting isn't random, as the two fugitives have something in common.
Grissom, Warrick, and Nick investigate the case of man who apparently was murdered and pushed off a six story building.
Mulder questions the sanity of an employee who believes his boss is a literal monster – until Mulder himself begins to perceive the presence of a hideous entity.
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