As AWAKE begins, police detective Michael Britten (Jason Isaacs) has just suffered a catastrophic car accident. He survived, but he now lives an intense double life that defies explanation. In one reality, his wife has survived, but his son has died; in the other, it's just the opposite. Other details vary, such as his partner on the police force and the crimes he's investigating. Suddenly he notices unexpected clues in each reality that help him solve impossible cases in the opposite world. As he works with two different psychologists, Michael struggles to piece together what's a dream and what's actually happening, all while trying to preserve every second he can in each reality with both his wife and his son.