Season 1

In Guerrero, Mexico, Don Miguel braces for competition as he struggles to keep control of the local poppy fields and protect his area. Back in Columbus, Ohio, Detective Mark Edwards orchestrates a traffic stop to close in on a local heroin dealer and starts to work his way up the chain. In Atlanta, Skyler moves back home with his parents to get clean, but a relapse threatens to tear his family apart.

Don Miguel responds to a shooting in his territory as drug-related violence in Mexico continues to escalate. In Columbus, Detective Mark Edwards investigates the overdose death of a young mother and tries to charge the person who gave her the deadly heroin. Nearby in Dayton, Richard runs a recovery clinic but is struggling to help his own daughter Brittany deal with her heroin addiction.

In the border town of Juarez, a drug trafficker explains how heroin is transported to the US while the Mexican Federal Police begin an operation to bust a big dealer in the state of Morelos, next door to Guerrero. In Columbus, Special Agent James executes a significant drug bust and begins to track the local heroin supply back to its cartel sources, but a key suspect disappears. In Atlanta, John hits the street to feed his habit before an impending court date, but feels guilty for manipulating his family.

Don Miguel celebrates a birthday as his rivals close in, while Mexican Federal police move to crack down on drug trafficking in Guerrero. In Columbus, Special Agent James tracks down the missing suspect that may be the key to breaking open his case. Meanwhile in Akron, Laura and Dan locate their fugitive son Andrew and convince him to turn himself in for outstanding drug charges and enter rehab.

In Columbus, Sergeant Nate Smith zeroes in on a dealer mixing heroin with lethal Fentanyl, but also helps recovering addicts get treatment. In Mexico, Don Miguel finds himself trapped in the drug trade, while Mario, a young activist, looks for his missing brother.  Back in Atlanta, Skyler signs himself up for long term treatment, but struggles to follow through.

In the wake of her husband’s execution by MS-13, Magda fears for her life. She flees Honduras with her young daughter, hoping to make it to the United States. In Colorado, restaurant owner Victor prepares his family for life without him as he awaits his next ICE hearing and possible deportation back to Guatemala. Special Agent Ramirez leads a Homeland Security investigation into a smuggling cell in McAllen, Texas. Season premiere