An 82-year-old woman appears to have committed suicide by overdosing on painkillers, but Dr. G finds evidence that suggests that she may have died of an heart attack. A former homeless man is found dead in his home the morning after complaining of a headache. Dr. G must find out how he died, but the 50-year-old man has no documented medical history. A 35-year-old woman dies in her sleep, and the hospital has no answer as to why she died. Dr G. works for three months to find a cause of death for her distraught family.

Dr. G preforms an autopsy on an alleged hit-and-run victim found in a parking lot, but finds no evidence of vehicular injury on the 41-year-old man's body. Could his alcoholism have had a role in his death? Dr. G investigates the death of a an 88-year-old woman found dead at the bottom of staircase outside her apartment building. Head trauma indicates that woman did not die of natural causes. Did she accidentally fall down the stairs or was she attacked? A man with a genetic disorder dies from a brain tumor at his 35th birthday party. His mother, who has another son with the same disorder, requests an autopsy to find out whether the tumor was linked to the genetic disorder. If so, is the brother of the victim at risk of dying in the same manner?

In August of 1995, when Dr. G worked in Bexar County, Texas, a pile of human bones was found at a supposedly haunted railroad crossing. Dr. G could tell that the victim was a teenager, but could not determine the sex. A DNA test said that the victim was male, but a 12-year-old girl told authorities that the bones were her sister's and that her sister had been murdered by her abusive mother. Her claim was unable to be verified and the authorities thought she was lying. The case went unsolved. Two years later, Dr. G found that the skull matched that of the girl reported missing, but why did the DNA test come back male, and how will that affect the case against the girl's mother? A 53-year-old man doesn't show up for work, and is found dead in his apartment. A neighbor says that the man was weak and dizzy the night before. Could the man's obesity have played a role in his death?

A 94-year-old woman dies in the hospital after having a convulsion. The case becomes the business of the medical examiner's office when no one will sign her death certificate. Dr. G finds no evidence of a heart attack or stroke. Could the woman's death be related to a childhood incident where she drank lye soap, or was it a complication of her recent hip surgery? A 24-year-old man falls off his bicycle onto the street and subsequently dies. He wasn't wearing a helmet, but a witness to the accident reported that the cyclist seemed to collapse before crashing. His mother says that prior to the accident, the man was acting as if he knew he was going die. Did he die from a head injury, was his death the result of his preexisting heart condition, or could he have been engaging in high risk behaviors that his family was unaware of? A 28-year-old stripper collapses in her home and refuses to go to the hospital. Later, she is found dead in bed. Her brother reveals that the woman used be a man, but recently had a sex change. Needle marks are found on her breasts, but no drugs are found in her system. Dr. G finds that silicone leaks from the puncture marks, but the woman had no breast implants. Had the woman been injecting her breasts with silicone, and did this somehow cause her death?

An infant and his two-year-old sister are found dead in a house shared by two families. At first, they are believed to have died from carbon monoxide poisoning or cold medicine overdoses. When Dr. G. examines the infant, she finds no apparent cause of death. However, when she examines the two-year-old, she finds teeth imprints on the insides of the child's mouth, indicating that someone had suffocated her. Since the girl's infant brother has no teeth, Dr. G assumes that he too was suffocated. After the police verify the alibis of all the adults living in the house, a 12-year-old girl from the other family living in the house becomes the prime suspect. At first she admits to committing the crime, but later denies it. The neighborhood is outraged that the police would accuse a child of murder, so the girl is sent to live with her grandparents. Not long after the girl moves in with her grandparents, the family dog is found dead. Dr. G must do an autopsy on the dog to find out whether it too has a been suffocated, and if that will be a significant piece of evidence in convincing a jury that the girl is guilty. A 25-year-old pregnant mother checks into a homeless shelter, and reports that she has ovarian cancer. A week later, she falls ill and dies on the way to the hospital. Dr. G first checks the woman's ovaries, but finds no evidence that the woman ever had ovarian cancer. The woman was overweight and had an enlarged heart, which meant that she was at risk of having high blood pressure and and developing blood clots. Were these risk factors what caused the young mother's untimely death?