Detective Sherlock Holmes, along with his sober companion, Dr. Joan Watson, uses his uncanny ability to read people and analyze crimes to assist the NYPD on some of their more difficult cases. In the season premiere, Holmes consults on a home invasion that resulted in murder.

Sherlock uses his powers of deduction to consult on the murder of a young man who is shot upon entering his apartment. Meanwhile, Watson has dinner with her ex-boyfriend. Jon Michael Hill joins the regular cast.

Sherlock and Watson consult on a child abduction case involving a serial killer who is nicknamed "The Balloon Man," because he leaves a signature batch of balloons at each of his crime scenes.

Even though he despises bankers, Holmes agrees to consult on a case involving the death of a Wall Street executive who appears to have overdosed on heroin. Meanwhile, with Holmes' encouragement, Watson tries to re-enter the dating scene. Craig Bierko guest stars.

Sherlock tries to determine who has been killing weak and terminal patients at a hospital, making it look like they died of natural causes. Meanwhile, Sherlock learns more about Joan's decision to walk away from her surgical career. Anika Noni Rose guest stars as Dr. Carrie Dwyer.

Sherlock tries to prove that one of people whose body was found in the wreckage of a small plane crash was actually killed before the plane went down. Meanwhile, Watson tries to convince Sherlock to meet with his elusive father.