Lucious Lyon, the head of a music empire, learns he has a disease and must choose one of his sons to take over his reign; Lucious' ex-wife tries to claim her share after being released from prison.

Lucious must defend Empire’s IPO launch after controversies arise around one of his artists being involved in a shooting, and Cookie proves to be invaluable by helping Lucious turn a crisis into a triumph. Competition between Lucious and Cookie heats up when Cookie hears of Lucious’s plan to stage a huge performance for Hakeem – but not Jamal. Meanwhile, the police begin to investigate Bunkie’s murder.

The Lyons head to Philadelphia and get a taste of what their life could have been if Lucious hadn’t made it big. Lucious promotes Hakeem’s new relationship with hip-hop star Tianna, but tensions rise when another woman tries to catch Hakeem’s eye.

Cookie receives an anonymous gift from an admirer that she believes might be a veiled threat from a person from her prison past. Meanwhile, Lucious takes charge of Hakeem’s first video shoot.

Vernon is caught in the middle of a very sticky situation. Meanwhile, Jamal is rising to stardom, but his newfound drive and ambition might stir up trouble in his relationships. To make matters worse, a mystery woman from the family’s past shows up with a huge surprise.