While working at an LGBT suicide hotline, Maura receives a distressing call from a young trans woman, Elizah. Afraid that Elizah will hurt herself, Maura goes on an odyssey through South Central LA to find the troubled teen and lands herself in the hospital.
After a health scare, Maura confronts death and her relationship to her body. Sarah hopes to join the MidCity Temple board. Shelly plans a onewoman show with Buzzy. Dissatisfied with their lives, Josh and Ali play married couple
Relationships are tested as the Pfefferman family gather for Maura's birthday. Sarah confronts Buzzy on temple board politics and Maura makes a big announcement, experiencing pushback from both Vicki and Shelly. The night culminates in a game of Sardines, forcing tense situations into tight spaces.
Maura gets an exciting peek at the future with a visit to the plastic surgeon's office but fails to muster the same enthusiasm from Vicki on a fun night out. Josh visits an unusually upbeat Rita while Ali and Leslie struggle with intimacy. Sarah finds distraction from her personal troubles by spearheading an unorthodox approach to Judaism.
The Pfefferman family gathers at Hineni to support Sarah's alternative spiritual endeavor. After the news of a close friend's untimely passing, a distressed Josh leans on Raquel for support. Ali ends the night by witnessing the pitfalls of Leslie's prejudices.
Josh hits the road with an unlikely copilot, stirring up some undeniable chemistry along the way. Back at home, Shelly becomes wary of Buzzy's outlandish spending while Ali sees God during a nitrous induced trip at the dentist's office.
Jeffrey Tambor
Maura Pfefferman
Gaby Hoffmann
Ali Pfefferman
Jay Duplass
Josh Pfefferman
Amy Landecker
Sarah Pfefferman
Judith Light
Shelly Pfefferman