In his continuing quest for a cure to the strange malady which turns him into a monstrous creature whenever he gets angry, research scientist David Bruce Banner finds himself in trouble in Philadelphia. In the City of Brotherly Love, Banner is rescued from a pair of muggers by a down-and-out prizefighter. Banner is concerned when he discovers that his new-found friend is mixed up in a shady dope operation that could spell his death. The Rocky-like contender has his heart set on a championship but it takes the Hulk to show him that he is not a contender.

David Banner gets a job at a zoo and finds a lovely young scientist proceeding with the genetic research he had started before being forced to become a homeless wanderer. Banner's interest in the experiments on research animals at the zoo creates a suspicion which is explained when he learns he has stumbled into the middle of a smuggling operation. Banner has to become the Hulk to save himself and the unsuspecting scientist from being victims of their own experiments.

David Banner suspects he might actually be a killer after he emerges from one of his blackouts as the Hulk at the scene of a murder. Haunted by the fear he may have killed a beautiful young model during his transformation as the Hulk, Banner returns to the scene of the crime and gets a job as a playboy’s valet. The job almost ends up with Banner a prisoner in a car headed for a trash compactor.

David Banner's search for a cure to the malady which turns him into a monstrous creature whenever he gets angry takes him to New York where he is unable to avoid his transformation after he gets involved in a Times Square skimming operation. While working in a Times Square arcade, Banner is warmly accepted by the owner and his daughter. The relationship is short lived after he has to resort to the Hulk to save his friends from a murder plot.

Bill Bixby is reunited with his former co-star, Brandon Cruz, in the story of a jetliner in trouble. The young Cruz guest stars as Kevin, who plays the only passenger on the plane with any knowledge of flying. He and the Hulk have to try and bring the jetliner to a safe landing after the plane's crew is disabled.

While working in a Las Vegas casino, David Banner aids an investigative reporter working on a gambling scandal and is put in the position of also helping his nemesis, McGee. When the reporter is injured in a murder attempt, he asks Banner to pass his information on to his friend McGee. Banner manages to avoid facing McGee, but, as the Hulk, ends up saving his life.