Zoey Brooks and her brother, Dustin, are heading Pacific Coast Academy, a private boarding school that is allowing females to enroll for the first time in its history.

Zoey's roommates, Dana and Nicole, constantly fight, so Zoey moves into a different room with a girl named Quinn who turns out to be far stranger than either of them.

Logan offers the girls a peace offering in the form of a stuffed animal, which turns out to be imbedded with a webcam that he uses to spy on them in their lounge.

When a school bully forces Dustin to do his homework for him, Zoey confronts the bully in public, embarrassing him and further enraging the bully.

When the boys TP the girls' dorm and bombard them with water balloons as part of the PCA tradition of "prank week," the girls devise a plan to get even which consists of defacing the statue in front of the boys' dorm. As it turns out, the son of the founder of PCA is on hand to witness the vandalism of his father's statue, and in a fit of rage, he decides it was a mistake to let girls into PCA. When Zoey takes sole blame for the prank, the founder’s son allows the other girls to stay, provided that Zoey accepts her expulsion and issues an apology to the entire student body. When the day of Zoey's address to the school comes, all students, male and female, have teamed up to pull one final prank and absolve Zoey once and for all.